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At T1D Exchange, we work to improve the lives of people with T1D through research. If you could ask a T1D scientist anything about research, what questions would you want answered? Share in the comments, and your question may be featured in an upcoming article!
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Do hormonal changes such as puberty, pregnancy and menopause impact the auto immune system in a way that triggers auto immune responses causing various conditions such as t1d, vitiligo, coeliac, thyroid conditions
A couple of questions:
1. Are there any emerging efforts or technologies which can enable CGM-like measurement of other molecules impacted by T1D (i.e. insulin)?
2. Immunotherapy seems to be a very hot area at the moment, specifically with regards to cancer treatment. Do you think that any treatment methods in cancer-specific immunotherapy will translate into benefits for other diseases, including autoimmune disease?
3. What do you feel are the most exciting and promising developments in the lab that will make it to the clinic in the next 5 years?
#3
How close are scientists to developing a smart insulin that works only as needed and stops working when blood sugar is normal or low?
Given that each T1D has different reactions to differing events at differing at differing times, have you studied why this may be or what is causing the above?
Why aren’t there more studies on heart disease risk with only T1Ds? I have read peer reviewed medical articles that confirm that T1Ds were not studied exclusively in statin research. We were advised to be treated with statins even if our cholesterol was excellent and there were no other risk factors. I suffered from elevated A1c, weight gain, insulin resistance, extremely low cholesterol which led to vitamin D deficiency which caused respiratory problems and inability to exercise or enjoy leisure activities due to breathlessness and muscle pain. Doctors believed that any symptoms reported by patients were due to the “Nocebo effect” despite my improvement when I didn’t take statins for six months when I forgot to refill my prescription! I suffered these side effects from 2002-2016 when I finally found a doctor who took me seriously. We need to be treated as individuals with T1D, not treated based on studies on the majority of T2 studies.
I agree with you GiGi. (And, I’m sorry you spent so long taking a medication you didn’t need.)
We know that studies can be problematic if there isn’t a variety of people involved, but how to fix that is a huge question.
I tried to sign up for some studies a long time ago but was turned away because of my diabetes. So, whatever study it was had no data for diabetics.
And, each of us is SO different in SO many ways! It’s annoying to be placed in an actuarial table and made to conform to something that doesn’t fit!
I have been useing old school methods for 70 years without any major D problems… why ???… I am 90 years OLD.
Is there research to do that could minimize mood swings due to low blood sugars?
Are we any closer to making pancreas transplants not only a regular treatment, but an affordable one?
Do you think we’ll ever get to a fully automated, closed-loop glucose delivery and CGM system? Is an artifical pancrease something that we could really see within the next 25 years?
Do you think that stem cell transplants (becoming new islet cells) will cure T1D in the next 25 years?
Last I heard about beta cell transplants was that they last about three years, and then the same auto-immune problem kicks in, and itās time to consider whether you can afford another transplant operation. Why not use CRISPR gene editing to solve the auto-immune problem? Is any research being done for T1Ds in this area?
if you cure type 1, how will big pharma top executives pay for their luxury sports cars and condos?
How do scientists choose what problems/questions to study?
Is the University of Virginia (UVA) Study Title: Adaptive Behavioral Control (ABC) in a Closed-Loop System: A Randomized Crossover Clinical Trial legitimate? I was approached today via email about a 6 month clinical study. The person I spoke with indicated I would receive 6 months of Dexcom CGM Transmitters and sensors. When I asked why I had to use those supplied by UVA her answer was “it is a controlled study.” It sounds legitimate, but I’m a little unsure? Does the name Principal Investigator: Sue Brown, MD ring a bell with anyone? There is a payment to participants of $400/6 month study with partial payment if I drop out during the study. UVA will download an app onto my phone allowing UVA’s WIP application to download my Dexcom readings and suggest tweaks to my basal and bolus settings. My readings will be reviewed with suggested adjustments every 14 days. This is all in the name of tighter control. Can anyone verify this study?
Hi Don. All clinical trials in the US need to be registered at clinical trials.gov and are assigned an NCT number. You can search that website using key words, study site, etc to confirm legitimacy. The website will provide an overview of the study. If you are interested in possible participating in the study, you will be asked to sign a detailed consent form that spells out the details so you can make an informed choice if you want to proceed. Hope this helps! š
Hi Don –
I didn’t find an HCT number that Jneticdiabetic mentioned on the UVA school of medicine site. But, I did see an HSR# of 220300.
Then I went to “clinicaltrials.gov” (thanks to Jneticdiabetic!!) and searched. This website does list the study you are looking for with the 220300 being an NCT# (not HSR as listed on the “med.virginia.edu” website.)
In my opinion and if it were me, I would think it is legit. But, that is me. I hope that helps!
Autoimmune conditions can be prevalent but variant in families. No one else has type 1 diabetes in mine, but many others: Addisons, Lupus, MS, we all share thyroid conditions.
Would there be a way to genetically test and prevent this from happening at birth?
What are the causes of increases in blood sugar levels that are not connected to food or activity. My blood sugar levels will just increase while I’m sitting & If I don’t catch it, it will go into the 200s. Very frustrating
Why is a cure so difficult to find?
I am a type 1 diabetic for about 40 years. I follow intensive insulin therapy. I have noted that that weather conditions affect the insulin intake quite drastically. Has there been any research findings on this?