31 Comments
Have you ever participated in a T1D focused clinical trial? Tell us about it in the comments!
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I was in the DCCT trial back in the 90’s
I incorrectly answered yes.
I have only participated in research, not clinical trials for diabetes.
Yes, I participated in an early closed loop clinical trial in ~2007. 3 days in the hospital, hooked up to 2 CGMs, a pump, and a laptop to control insulin delivery. So cool to think how far tech has come since then. Auto mode in real life – no lap top required!
Not to succumb to that evil trait of cynicism but, . . . I somehow feel my entire life has been a T1D closely focused clinical trial. 🥱
In the mid 80s I participated in a trial at the National Institute of Health that was investigating the effects of a medication on the capillaries of the retina, to determine whether the medication w/could help prevent diabetic retinopathy.
I completed all of the trial papawork in person at the clinic. I was called 3 days later and told that I did not qualify because my A1c was too low. I was at 5.9 then. The clinical drug turned out to be Mounjorno.
Yes, for Medtronic as they were seeking further trial data for approval in several countries in Asia of their 680G and Sensor 2 AID system. This was also at the beginning of the Time In Range understanding of glucose control and we were part of that study also. All of this required me to travel to the International Diabetes Center in a Minneapolis suburb multiple times over a year.
applied for a Vertex trial without immunosuppression drugs. my A1C was lower than the range they wanted for the survey.
I had been on insulin pumps for over 20 years. I entered a drug trial on long acting injectables and found I had much better control with shots than with the pump. I have been on shots ever since, 15+ years.
No – I tried and everything was fine until they found out my A1C was less than 7 🙁
I can relate to that, Nevin.
On one trial 3 years ago I was eliminated after a year of evaluation because my HbA1c was 3 percentage points too low.
I participated in the Faustman lab BCG trial.
I participated in the trial for TANDEM’S CONTROL IQ, and several Dexcom G7 adhesive trials.
I’ve participated in several trials over the years; some whuch proved successful for continuing and, more that didn’t work out as expected. Three of the “successes” were:
1) A four year trial in the 1960s to determine if a Ruby LASER might work to contain Retinopathy. Later a few other eye experiments.
2) In 1974 the development of the successful glycosylated hemoglobin test study; test later referred to by its chemistry symbols as HgA1c and HbA1c,
3) 1977 – 1979 development [before digital BG meters] of what has now become known as MDI. Our work was validated through the Worldwide DCCT Study of the 1980s.
PERL: allopurinil, fenophibrate, bone loss.
I met with and gave blood to Dr Faustman in Boston. It seemed so hopeful back in 2007ish.
I have been a part of several clinical trials. One I was very happy to be a part of as it was for inhalable insulin. Unfortunately, the trial was halted midway through with the company deciding not to go forward with the product. I was very glad that Mannkind continued with their production and release of Afrezza, as I did super with the inhalable insulin as opposed to multiple injections.
Years ago I supplied bloodwork. Happy to help
The effects of hypoglycemia on the brain as measured by MRI as well as cognitive testing at Yale-New Haven hospital. Also, Dr Faust’s BCG trial in Boston, MA
Faustman–not Dr Faust.
In the 80’s I participated in a trial for early treatment for retinopathy. They did laser treatment on one eye and at end of study did laser on the other eye. Was given a pill or placebo to see if aspirin affected outcome. I developed an ulcer so was taken of off pill/placebo
No, but I was told by my endocrinologist that one may come up close to me that will focus a pump giving glucagon and insulin. If that trial does come close to my home, I might try that one.
Never seem to qualify!!
I participated in the clinical trial testing the effectiveness of Tresiba versus Lantus
About ten years ago, I did a trial with a medication that was meant for T2Ds that they also wanted to maybe try on T1Ds. I don’t remember what it was called, and I don’t even know if it got approved. I just know it wasn’t a weight loss drug
DCCT/EDIC, 39 years and counting.
I participated in one for the essence sensor but it was just to see how the readings went on the device, not the sensor being inserted.
PERL, PERL-age
U have been in Phase 1,2 and 3 trials. Sometimes with placebo sometimes with investigational drug. First trial I ever did caused some problems and couple of deaths- trial stopped and drug did not proceed. I had some lingering health issues but have continued to volunteer. The drugs that I trialed that made it to market are inhaled insulin. And an SLG1 inhibitor. I have also tested new meters and been in a focus group to review directions for devices to make sure the language and directions were easy to follow.
I just started one!
It’s fascinating… the names of the chemicals/hormones they are testing elude me at the moment. It has something to do with what insulin tells the liver to do… I didn’t know insulin had another job in the body other than lowering blood sugar!
Vertex Clinical Trial