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    • 30 minutes ago
      Ahh Life likes your comment at
      Have you heard about tegoprupart, an immunosuppressant alternative with fewer side effects than traditional immunosuppressants, now being used for islet cell transplantation?
      This question is an advertisement. In my opinion it is a misleading advertisement. Tegoprupart is an immunosuppressant. A trial investigating using the drug with islet cell recipients has barely gotten started. 90-ish percent of all phase 3 drug trials fail. Drug development is hard. I wish them luck at the same time I wish they weren't misleading people about the investigational use of their drug.
    • 1 hour, 34 minutes ago
      Marthaeg likes your comment at
      Have you heard about tegoprupart, an immunosuppressant alternative with fewer side effects than traditional immunosuppressants, now being used for islet cell transplantation?
      I'd sign up today!!!!! Have to admit that listening to her describe her "freedom" with "no longer having" T1D makes me jealous!
    • 1 hour, 34 minutes ago
      Marthaeg likes your comment at
      Have you heard about tegoprupart, an immunosuppressant alternative with fewer side effects than traditional immunosuppressants, now being used for islet cell transplantation?
      I follow Katie Beth Hand and Crushingt1 lots of great info on the Eledon trial. I would definitely sign up for the trial if I was eligible.
    • 3 hours, 13 minutes ago
      Gerald Oefelein likes your comment at
      Have you heard about tegoprupart, an immunosuppressant alternative with fewer side effects than traditional immunosuppressants, now being used for islet cell transplantation?
      AI Overview Tegoprubart, an anti-CD40L antibody, is generally safe and well-tolerated, with a cleaner safety profile than traditional calcineurin inhibitors (like tacrolimus) in early trials, specifically showing lower risks of kidney toxicity and diabetes. Common side effects reported include fatigue, headaches, muscle spasms, and potential infections. National Institutes of Health (.gov) National Institutes of Health (.gov) +4 Common Side Effects and Adverse Events In clinical trials, the most frequent treatment-emergent adverse events (TEAEs) observed included: National Institutes of Health (.gov) National Institutes of Health (.gov) +2 Fatigue (approx. 25.9%) Falls (approx. 22.2%) Headaches (approx. 20.4%) Muscle spasms (approx. 11.1%) Upper respiratory tract infections Sleepiness Key Safety Advantages Over Standard Care (Tacrolimus) Tegoprubart aims to avoid the, often, severe, long-term side effects of standard anti-rejection meds like tacrolimus
    • 3 hours, 14 minutes ago
      Lawrence S. likes your comment at
      Have you heard about tegoprupart, an immunosuppressant alternative with fewer side effects than traditional immunosuppressants, now being used for islet cell transplantation?
      No thanks.
    • 22 hours, 54 minutes ago
      Gerald Oefelein likes your comment at
      If islet cell transplantation is proven safe and effective, how likely would you be to consider it a treatment option?
      Without rejection drugs- very likely. With rejection drugs- not a chance.
    • 22 hours, 55 minutes ago
      Gerald Oefelein likes your comment at
      If islet cell transplantation is proven safe and effective, how likely would you be to consider it a treatment option?
      Only if I don't need to take any immunosuppression drugs
    • 22 hours, 55 minutes ago
      Gerald Oefelein likes your comment at
      If islet cell transplantation is proven safe and effective, how likely would you be to consider it a treatment option?
      All depends on if anti rejection and immunosuppressive medications are needed. If so I would not be interested.
    • 22 hours, 55 minutes ago
      Gerald Oefelein likes your comment at
      If islet cell transplantation is proven safe and effective, how likely would you be to consider it a treatment option?
      It would depend on the cost and coverage by insurance as well as the requirement for immunity suppressants.
    • 22 hours, 55 minutes ago
      Gerald Oefelein likes your comment at
      If islet cell transplantation is proven safe and effective, how likely would you be to consider it a treatment option?
      Very likely provided immunosuppressants aren't required. Also younger people should receive the treatment first.
    • 22 hours, 56 minutes ago
      Gerald Oefelein likes your comment at
      If islet cell transplantation is proven safe and effective, how likely would you be to consider it a treatment option?
      as long as it doesn't require immunosuppression, I'm interested
    • 22 hours, 56 minutes ago
      Gerald Oefelein likes your comment at
      If islet cell transplantation is proven safe and effective, how likely would you be to consider it a treatment option?
      If it requires immunosuppressive medication I have no interest. I'll continue to manage with insulin.
    • 22 hours, 58 minutes ago
      Lawrence S. likes your comment at
      If islet cell transplantation is proven safe and effective, how likely would you be to consider it a treatment option?
      Without rejection drugs- very likely. With rejection drugs- not a chance.
    • 22 hours, 59 minutes ago
      Lawrence S. likes your comment at
      If islet cell transplantation is proven safe and effective, how likely would you be to consider it a treatment option?
      Very likely, especially if stem-cell generated islet cells are transplanted without the need for immunosuppressants. If tegoprubart is needed and is found safe after the trials are complete, then likely.
    • 22 hours, 59 minutes ago
      Lawrence S. likes your comment at
      If islet cell transplantation is proven safe and effective, how likely would you be to consider it a treatment option?
      Only if I don't need to take any immunosuppression drugs
    • 22 hours, 59 minutes ago
      Lawrence S. likes your comment at
      If islet cell transplantation is proven safe and effective, how likely would you be to consider it a treatment option?
      All depends on if anti rejection and immunosuppressive medications are needed. If so I would not be interested.
    • 23 hours ago
      Lawrence S. likes your comment at
      If islet cell transplantation is proven safe and effective, how likely would you be to consider it a treatment option?
      It would depend on the cost and coverage by insurance as well as the requirement for immunity suppressants.
    • 23 hours ago
      Lawrence S. likes your comment at
      If islet cell transplantation is proven safe and effective, how likely would you be to consider it a treatment option?
      Very likely provided immunosuppressants aren't required. Also younger people should receive the treatment first.
    • 23 hours ago
      Lawrence S. likes your comment at
      If islet cell transplantation is proven safe and effective, how likely would you be to consider it a treatment option?
      Very likely. Although the simplicity of spifflicating is often overrated. 🤓☝️
    • 23 hours ago
      Lawrence S. likes your comment at
      If islet cell transplantation is proven safe and effective, how likely would you be to consider it a treatment option?
      as long as it doesn't require immunosuppression, I'm interested
    • 23 hours, 1 minute ago
      Lawrence S. likes your comment at
      If islet cell transplantation is proven safe and effective, how likely would you be to consider it a treatment option?
      I was going to comment that there's always a trade off. Am I trading insulin replacement with some other daily treatment? If so, what's the difference? Is the new daily grind more harmful than the old?
    • 23 hours, 1 minute ago
      Lawrence S. likes your comment at
      If islet cell transplantation is proven safe and effective, how likely would you be to consider it a treatment option?
      If it requires immunosuppressive medication I have no interest. I'll continue to manage with insulin.
    • 23 hours, 1 minute ago
      Lawrence S. likes your comment at
      If islet cell transplantation is proven safe and effective, how likely would you be to consider it a treatment option?
      I am too old and prefer my daughters get islet cells. There isn’t going to be enough to treat everyone I am sure as the supply will not allow that
    • 23 hours, 57 minutes ago
      Patricia Dalrymple likes your comment at
      If islet cell transplantation is proven safe and effective, how likely would you be to consider it a treatment option?
      as long as it doesn't require immunosuppression, I'm interested
    • 23 hours, 57 minutes ago
      Patricia Dalrymple likes your comment at
      If islet cell transplantation is proven safe and effective, how likely would you be to consider it a treatment option?
      I was going to comment that there's always a trade off. Am I trading insulin replacement with some other daily treatment? If so, what's the difference? Is the new daily grind more harmful than the old?
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    If you’re a person with T1D, have you experienced symptoms of Raynaud’s phenomenon (a condition where the hands or feet experience temporarily less blood flow, become very cold, and may turn white or blue)?

    Home > LC Polls > If you’re a person with T1D, have you experienced symptoms of Raynaud’s phenomenon (a condition where the hands or feet experience temporarily less blood flow, become very cold, and may turn white or blue)?
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    Has your career path been influenced by living with T1D or having a loved one with T1D?

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    Do you use any type of creams or ointments after removing your pump, CGM or injection site needle to prevent infection? Share in the comments what works for you!

    Sarah Howard

    Sarah Howard has worked in the diabetes research field ever since she was diagnosed with T1D while in college in May 2013. Since then, she has worked for various diabetes organizations, focusing on research, advocacy, and community-building efforts for people with T1D and their loved ones. Sarah is currently the Senior Marketing Manager at T1D Exchange.

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    11 Comments

    1. Jane Cerullo

      I have symptoms in both little fingers but have had surgery for Duputrens on both. So not sure raynauds or from surgeries. Very annoying. And can be painful.

      4 years ago Log in to Reply
    2. Sherolyn Newell

      No, and I hope I never do. That sounds scary.

      4 years ago Log in to Reply
    3. Lawrence S.

      I said, “maybe”. However, I am certain that I do have Raynaud’s. It just has not been diagnosed by a medical professional. Several of my siblings have been diagnosed with Raynauds. Throughout my whole life, I have had cold hands and feet, continuously. I feel cold most of the time, and am unable to live in cold weather (winter). As a matter of fact, I moved from the northern part of the USA to the southern part of the country specifically for that reason.

      4 years ago Log in to Reply
    4. Merry Woolsey

      I have had it in the past but not in recent years. I did have an MD tell me I did at that time, 2010, but no skin color change since 2015.

      4 years ago Log in to Reply
    5. TomH

      I’ve experienced instances of hand going numb, but attribute it to laying my head on it and cutting off normal blood flow similar to a compression low with a G6 CGM. There’s no pain, no color change that I’m aware of (hey its at night, in the dark…), no noticeable temperature change (think its a short-lived event), and it resolves quickly after changing position.

      4 years ago Log in to Reply
    6. Carol Meares

      The diagnosis from my doctor was based on my own testimony. Raynauds for me has been a regular occurrence since before my diabetes diagnoses. I have had Raynauds for probably 35-40 years.

      4 years ago Log in to Reply
    7. Liz Avery

      I don ‘t have problems but I have family members that are not diabetic that do.

      4 years ago Log in to Reply
    8. Karen Taylor

      I answered too quickly. I have not been medically diagnosed with Raynaud’s however have all the symptoms.

      4 years ago Log in to Reply
    9. Molly Jones

      I was diagnosed with this five years ago after experiencing progressive symptoms for more than twenty+ years.
      I can cool my husband down very quickly with my hands and feet most any time of the day, except when I first wake up after lying in bed. Most of my body is warm then.
      I also use mittens and hand warmers many times of the years when others are warm. I also like my drinks to be room temperature. Ice hurts and can give my lips a blue tinge.
      I find it strange that I hate the heat though. I cannot cool down once it’s over a certain comfortable temperature. Maybe the same blood flow problem leads to this?

      4 years ago Log in to Reply
    10. Melinda Lipe

      Maybe – I have severe pain in my hands when I touch ice.

      4 years ago Log in to Reply
    11. AnitaS

      My hands do get very cold at different times. My left hand tends to get cold at breakfast and sometimes either hand will get cold while walking a dog. My hands don’t get white or blue however.

      4 years ago Log in to Reply

    If you’re a person with T1D, have you experienced symptoms of Raynaud’s phenomenon (a condition where the hands or feet experience temporarily less blood flow, become very cold, and may turn white or blue)? Cancel reply

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