Findings shed new light on potential prevention of diabetic kidney and heart disease in patients with type 1 diabetes
Men with type 1 diabetes and albuminuria have greater copeptin concentrations than men with normoalbuminuria, according to researchers at the University of Colorado. The findings were published today in the Journal of Diabetes and Its Complications.
Albuminuria is a form of protein found in urine that can be linked to kidney disease, particularly in people with type 1 diabetes. Utilizing T1D Exchange’s Biobank, researchers analyzed samples from 38 males with type 1 diabetes and albuminuria (men with abnormal levels of the protein in their urine) and 38 males with type 1 diabetes with normoalbuminuria (men with normal levels of the protein in their urine).
The findings suggest men with T1D and abnormal levels of the protein in their urine have greater concentrations of copeptin compared to men with T1D and normal levels of the protein in their urine. While further studies are needed to determine whether copeptin can play a role in the development of diabetic kidney disease, this research is promising as copeptin is a modifiable biomarker that can be altered with drugs already on the market.
T1D Exchange’s Biobank is a centralized bank of thousands of biological samples. The Biobank aims to be a world-class resource for innovative research by centralizing thousands of biological samples—together with clinical, demographic, and study-derived information.
“T1D Exchange’s Biobank was incredibly useful for our research. The population of people living with type 1 diabetes in one area tends to be fairly homogenous and it is often hard to find diverse sample groups,” states Petter Bjornstad, M.D., principal investigator of the study and Pediatric Endocrinology Fellow at Children’s Hospital Colorado “The Biobank stores blood samples from people with type 1 diabetes nationwide, which made it simpler for my team to complete our research and discover such a promising solution to such a life-threatening disease in patients with type 1.”
Diabetic kidney disease (DKD) is a major cause of mortality in type 1 diabetes, and emerging data suggest the arginine vasopressin (AVP) system plays an important role in the development of cardio-renal disease. However, measuring AVP is cumbersome. Copeptin is a more stable peptide derived from the same precursor molecule as AVP and is recognized as a surrogate marker for AVP, which is why researchers chose to focus on copeptin concertation’s for this study.
This study was published in Journal of Diabetes and Its Complications, “Albuminuria is associated with greater copeptin concentrations in men with type 1 diabetes: a brief report from The T1D Exchange Biobank.”