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PATIENT-REPORTED SEVERE HYPOGLYCEMIA AMONG HYBRID CLOSED LOOP SYSTEM (HCLS) USERS: REAL-WORLD EVIDENCE FROM A MULTI‐CENTER STUDY FOR PEOPLE WITH TYPE 1 DIABETES
O. Ebekozien1, N. Noor2, J. Lee3, R. Izquierdo4, L. Golden5, B. Miyazaki6, M. Wilkes7, M. Scott8, A. Mekhoubad9, J. Sanchez10
Background and Aims: Background: There is growing evidence that Hybrid Closed Loop Systems (HCLS) are associated with a lower risk of severe hypoglycemia (SH) in people with type 1 diabetes. In this study, we use real‐world data from the T1D Exchange (T1DX‐QI) EMR database to investigate the association between HCLS use and patient‐reported SH events using propensity score matching.
Methods: In this analysis, we examined SH events across propensity score‐matched HCLS user and HCLS non‐user groups. All available data for the pediatric (6 years and older) and adult population with T1D from March 2018‐March 2022 were included in this analysis. Patient‐reported SH events are defined as SH events reported by the patient at their most recent clinic visit and were classified as a binary variable (Yes/No), with those reporting one or more SH events being classified under ‘Yes’ Similarly, HCLS device use was defined as the use of HCLS reported by the patient at their most recent clinic encounter.
Results: Propensity scores were estimated using a logit model, including age, gender, race/ethnicity, and insurance status as covariates. Matching was done using 1:1 matching with the nearest neighbor approach and a caliper of 0.1. There were 1537 matched people with T1D in the HCLS user and non‐users group. Analysis showed that HCLS users were less likely than HCLS non‐users to report >1 SH event (OR [95% CI]: 0.2 [0.1, 0.4] when controlling for covariates.
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Closed-loop System and Algorithm: Patient-Reported Severe Hypoglycemia Among Hybrid Closed Loop System Users
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